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Tuesday, April 28, 2015

Can Sugar be Addicting?

by Michael Kuhar, PhD



Editor’s Note:

Dr. Kuhar is a Candler Professor at the Yerkes National Primate Research Center and Senior Faculty Fellow in the Center for Ethics at Emory University.  An expert in addiction, he is one of the most productive and highly cited scientists worldwide.  He has received a number of prestigious awards for his work, and is involved in many aspects of brain/behavioral research and education.



You might be interested in his book: The Addicted Brain





Recently, Constance Harrell facilitated an Emory Neuroethics Program Neuroscience and Neuroethics in the News Seminar on sugar and depression. Obesity became a topic and, not surprisingly, out of this discussion arose the question, “Can sugar be addicting?”  This is closely related to the question, “Can food be addicting?”



Somebody might say, we need sugar/food to be healthy, and we can’t do without them, so how can we say they are addicting?  Well, there is an answer to this.  Addiction, by definition, is seeking and taking a substance even though there are negative consequences.  Negative consequences are key. So if we take a substance but there are no negative consequences, addiction wouldn’t be in the discussion.  The question of danger for addiction and abuse might be, but definite addiction probably wouldn’t be (Kuhar 2012).



Consider taking opiates for pain.  Chronic pain patients repeatedly take morphine or similar medicines for a long time.  These patients are “dependent” because if they stop the drug, they go into painful withdrawal. But they are not “addicted” because they don’t compulsively seek out the drug and experience negative consequences.  This would be different from the addict who searches for heroin and in doing so breaks the law, ignores relationships, health, and work, etc.  So you can “need” something but yet not exhibit the key identifier of addiction, which is seeking and taking even though they are destructive.  We can need food, but yet not experience it as destructive, provided it is taken in moderate quantities and provides necessary nutrients. But perhaps some do experience the negative. As with drugs, there are interpersonal variations in how we experience sugar.  An extreme case would be a person with diabetes where taking sugar is more dangerous.



Also, the effects of drugs (and presumably sugary foods) will depend on the dose or amount taken.  High doses of drugs can have effects that low doses do not.  So having high doses of sugary foods can have effects in the body that low doses do not really produce. So sugar is not always sugar.  The dose or quantity that you consume, and how often you consume it, can have unique effects that you won’t necessarily experience at lower doses and frequencies. Such dose-response relationships are well known and well-studied in pharmacology and research (Kuhar 2012).



Drug abuse studies show that most people can walk away from drugs like heroin, but some don’t (maybe 1-13 % by some estimates depending on the substance) and become or are addicts. Translating that to sugar, only a small percentage of sugar “users” would be “addicted.”



What is the official position on sugar and food as addicting?  At this point in time, many feel that there are not enough peer reviewed studies that show food is addicting (DSM-5, 2013).  The studies just haven’t been done yet.  Some suspect that once the research has been conducted, sugar and food will fit the criteria for being addicting in some people.  We will see.



There is some evidence that is compatible with sugar being addicting (Schreiber et al 2013; Hone-Blanchet and Fectaeu, 2014; Ahmed et al 2013;Kenny et al 2013; Hadad and Knackstedt 2014; Tau and Potenza 2013). Some people eat sugary foods in ways and quantities that are not healthy, and therefore they have negative consequences.  Obesity is on everyone’s mind. Eating sugary foods regularly can also result in craving and a loss of control, hallmarks of addictive behavior.  Sugar can make you feel good, just like addicting drugs can. Sugar can be taken in binges, just like drugs. Stress can precipitate both drug taking and eating. Some research even suggests that sugar can be more rewarding than cocaine (Lenoir et al 2007). Brain scans of dopamine receptors in obese subjects are similar to those from drug addicts (Kenny et al 2013). And more can be said. At this point in time, many feel that sugary foods can be addicting in some, and that this eventually will be proven in rigorous ways.



What makes a sugar/food addict?  Well, again extrapolating from findings in drug abuse and addiction, there could be several factors that increase our vulnerability for addiction.  We don’t know enough to say for sure when and how a specific person will be an addict.  We can only consider large populations of addicts and look at how they are and how they behave.  The main vulnerability conferring factors include genetics, environmental factors including personal support, conditioning, and stress.  Also, there are protective factors such as a very supportive environment (Kuhar 2012).



What do we do if we are in trouble?  Get counseling.  Pay attention to risk factors and work to counteract them. In drug addiction, the more time spent in rehab gives a better outcome by staying away from drugs.  It takes work and a significant time commitment, and many people have been and will continue to be helped.



Selected Readings



Ahmed SH, Guillem K, Vandaele Y. Sugar addiction: pushing the drug-sugar analogy to the limit. Curr Opin Clin Nutr Metab Care. 2013 Jul;16(4):434-9. doi: 10.1097/MCO.0b013e328361c8b8.



DSM-5. American Psychiatric Association.  2013. P 481. “ …groups of repetitive behaviors, which some term behavioral addictions, with such subcategories  as sex addiction (and presumably food addiction)… are not included because at this time there is insufficient peer reviewed evidence…to identify these behaviors as mental disorders.”



Hadad NA, Knackstedt LA. Addicted to palatable foods: comparing the neurobiology of Bulimia Nervosa to that of drug addiction. Psychopharmacology (Berl). 2014 May;231(9):1897-912. doi:10.1007/s00213-014-3461-1.



Hone-Blanchet A, Fecteau S. Overlap of food addiction and substance use disorders definitions: analysis of animal and human studies. Neuropharmacology. 2014 Oct;85:81-90. doi:10.1016/j.neuropharm.2014.05.019. Epub 2014 May 24.



Kenny PJ, Voren G, Johnson PM. Dopamine D2 receptors and striatopallidal transmission in addiction and obesity. Curr Opin Neurobiol. 2013 Aug;23(4):535-8.



Kuhar, MJ.  The Addicted Brain.  FT press. Upper Saddle River, NJ. 2012.



Lenoir M, Serre F, Lauriane L, and Ahmed SH. Intense Sweetness Surpasses Cocaine Reward. PLoS ONE. 2007; 2(8): e698. Published online 2007 Aug 1. doi:10.1371/journal.pone.0000698.



Yau YH, Potenza MN. Stress and eating behaviors. Minerva Endocrinol. 2013 Sep;38(3):255-67.



Want to cite this post?



Kuhar, M. (2015). Can Sugar be Addicting? The Neuroethics Blog. Retrieved on , from http://www.theneuroethicsblog.com/2015/04/can-sugar-be-addicting.html

Wednesday, April 22, 2015

Hot off the presses! Ethical issues with direct-to-consumer neuroscience

Ethical issues with Lumosity and other Direct-to-Consumer Brain Training
Games by Emory Neuroethics Program Director and AJOB Neuroscience Editor-in-Residence, Dr. Karen Rommelfanger and AJOB Neuroscience editorial intern Ryan Purcell.



Article is open access here for the next 50 days until June 11, 2015.









"Internet brain training programs, where consumers serve as both subjects and funders of the research, represent the closest engagement many individuals have with neuroscience. Safeguards are needed to protect participants’ privacy and the evolving scientific enterprise of big data."

Tuesday, April 21, 2015

A Special Event Reprise: Exploring the Ethics of Cognitive Enhancement and the University's Policy at Emory

Last month, Emory’s Committee on Academic Integrity and the Barkley Forum collaborated to host “Study Drugs: Exploring the Ethics of Cognitive Enhancement and the University’s Policy.” The program featured a debate among four Emory University undergraduates and a discussion between Emory Center for Ethics's very own Dr. Karen Rommelfanger and Dr. John Banja in addition to Willie Bannister, Emory’s Associate Director of Health Promotion. This event, organized by Emory University senior Grant Schleifer, brought out students from many areas of study to weigh in on how the university can better address the potential issue of increasing usage of cognitive enhancement drugs within Emory’s student body.



In an effort to relay the contents of the event to the greater student body, the speeches from the event are displayed below in the order of their presentation. This 20-minute debate included two affirmative speeches advocating that Emory ought to take a stance on the use of cognitive enhancement drugs and set up a regulatory regime to oversee students’ use of cognitive enhancers.  The negative team argued against this approach to the “study drugs” problem by presenting potential negative consequences to greater monitoring of the intake of cognitive enhancers, such as creating a larger black market for drugs like Adderall.



Further, Dr. Jason Ciejka, Emory’s Associate Director of the Honor Council attended this event and provided us with a wonderful commentary on the proceedings. Given his role at the university, his perspective on issues such as cognitive enhancement is incredibly valuable and aids in further understanding the intersection of ethics and policy at the university level. His commentary along with the content of all the speeches from the event will demonstrate how academics, administrators, and students can collaborate to discuss thorny ethical issues that impact all Emory community members and will hopefully stimulate further discussion on this blog.








The First Affirmative Speech


By: Javi Reyes




In an effort to keep up with the rigorous collegiate academic climate, students have chosen to pick up a peculiar study habit. Drugs like Adderall are being popped like Advil to obtain an academic advantage. These forms of medication are usually used to treat individuals who suffer from Attention Deficit Hyperactivity Disorder (ADHD) and Attention Deficit Disorder (ADD). George Krucik says that these sorts of drugs are designed to improve hyperactivity, impulsive behavior, and attention span. According to the Cleveland Clinic, stimulants improve symptoms of ADHD in 70 to 80 percent of children and 70 percent of adults. Despite the short-term positive affect, abusing these drugs is cheating and dangerous.



According to a study released by the University of Texas, these cognitive stimulants have the potential to result in an over-dependence on the drug, which will lead to higher doses and eventually inability to concentrate without it. Without these study drugs, students from across the country have contributed personal testimonies that have a recurring theme: abusers of this drug lack all motivation when off of a drug and experience varying degrees of withdrawal immediately after increased usage and dosage.  Along with the increased concentration, there is a tradeoff with sleep and an increase in heart rate. According to Edward Bell, professor of clinical sciences at Drake University College of Pharmacy, “most people that take the drug at a normal dose to study for the night may not experience any sudden side effects, but it may aggravate a potential heart problem.” Furthermore, the exploitation of the body’s dopamine levels reduces energy substantially, leading to exhaustion and potentially resulting in long-term side effects like anxiety and depression.



The worst effects of study drugs come to the surface when it is mixed with other drugs and alcohol. Dr. Emily Kensington says that study drugs “cover up” the effects of alcohol, which means students may not recognize how intoxicated they may be, which raises the risk of alcohol poisoning. A study released by the National Survey on Drug Use and Health reported that up to 90 percent of full-time students using Adderall recreationally participated in binge drinking episodes in the last year.



Despite arguments for the decreased usage of drugs like Adderall and Ritalin, according to Martha Farah, director at the Center for Cognitive Neuroscience at the University of Pennsylvania, 1 in 4 college students on some campuses have abused study drugs. And as reported by TIME magazine, Ivy League institutions and other highly ranked universities exhibit about 20% usage.



Beyond the health factors, cognitive stimulants could be considered cheating. It is illegal for students who are not prescribed the drug to use or possess these types of enhancements. Similar to using steroids for athletic competitions, it gives students who abuse the drug an academic edge over those who do not use or cannot obtain Adderall.



In order to address the problem, Emory University should implement a regulatory regime and generate an education process similar to AlcoholEdu and Haven to highlight the health risks to abusing drugs such as Adderall and Vyvanse.



Despite the fact that the solution may not be able to prevent the students who want the drug to obtain it, it is important for Emory to take a position on the matter and ensure the healthiness of its student body. This proposal may add on to existing preventative measures that curb the use of study drugs.



When the health of a university’s students and academic integrity are at stake, the effort to mitigate the negative effects outweighs the alternative to allow for the unregulated and uneducated use of highly addictive drugs on Emory’s campus.




The First Negative Speech


By: Mili Raina



While we can agree that usage of study drugs such as Vivance, Adderall, and Ritalin may be on the rise, a regulatory regime is not the way to go about fixing this problem.



Firstly, how would this regulatory regime work? There are massive problems with establishing a regime that keeps track of students’ medications and forces them to attend mandatory counseling to investigate whether or not they are abusing that drug – it antagonizes students who have ADHD and creates a culture of distrust of Emory healthcare professionals. Students suffering from depression, stress, tests, and other problems would think twice before consulting Emory counseling and psychological services as they could be fearful that anything they say would be reported to the Honor council or other disciplinary committee. Instead of going to speak to a counselor about their addiction to Vivance, they would keep using it because a conversation with a counselor would put them in danger of getting an honor code violation. This would escalate, as students with other abuse problems or even depression and anxiety disorders would become suspicious of the services they were assured were “confidential” and stop seeking help.



According to a study by the Anxiety and Depression Association of America, anxiety disorders are one of the most common mental health problems on college campuses. Forty million U.S. adults suffer from an anxiety disorder, and 75 percent of them experience their first episode of anxiety between age 17 and 22. 80 percent say they frequently or sometimes experience daily stress. As a student of Emory college and having seen the cutthroat competition of the business school, I understand the pressure and stress students feel to turn to study drugs to give them the edge on tests and papers. Maybe we should instead question the learning environment before accusing study drug users of cheating and judgmentally imposing our morals on them.



After all the progress these departments have made in the past couple years, a haphazard attempt to control study drugs would put Emory’s students at more risk than if there was no regulatory regime.



Secondly, the regulatory regime would only create a larger black market of illegal drugs.  Just like students who use marijuana, the students who obtain study drugs from prescription owners on campus would shift to other dealers. This means that the regulatory regime wouldn’t catch any students who buy these study drugs illegally but put unneeded pressure on students who actually have ADHD.



For this reason the regulatory regime would make no true progress in enforcing the honor code.




The Second Affirmative Speech


By: Mollie Fiero 





Emory University ought to implement a regulatory regime in order to combat the physical harms of study drugs as well as to take a public stance against them. They should be backed by punitive force as well as the ability to mandate counseling and health follow-up services.



I’d like to begin by introducing an additional point of consideration – the inherent unequal access to these drugs. Emory offers many different kinds of study aids or techniques for students to get a leg up; university services like EPass, OUE, CAPS, and individual professors are able to give opportunities to all students to further their academic careers. We would take no objection to students trying to master their subjects or expand their knowledge. However, study drugs are a privilege reserved only for the economic elite. Emory prides itself on racial and socioeconomic diversity, among other things, and study drugs, acquired either on the “black market” or through a corrupted physician, require hefty sums of money that only the wealthy can take advantage of. A study at the University of Texas labeled the dangers of study drugs as ones that primarily concern wealthy, white students. Although the dangers may be exacerbated for this group, that means the access is primarily limited to this group as well. We cannot turn a blind eye to the economic inequality and performance “benefits” exacerbated by these drugs.



Although it may be true that ADHD is an instance of a false or unnecessary pathologization of a variety of so-called symptoms, this is irrelevant to the central question of this debate. These drugs exist, they are used, and abused. Even if we ought to change our approach to disease and treatment, this may be an apt critique of the Western medical model but the proposed alternative is long-term at best. In the short term, we have an obligation to recognize the dangers to our student population.



Our opponents have said that a regulatory regime may not be an effective response to the study drugs problem. There are two primary responses to this argument. The first is the value of norms on our campus. Not only would an informative program similar to AlcoholEdu provide a base level of knowledge about the dangers of these drugs, it would catalyze on-campus discussions and dialogue regarding their use. Were the university to formally prohibit their use, it could further a system of beliefs that sides with academic honesty and hard work over the abuse of study drugs. The second argument is the importance of education. Simply by requiring and implementing this regulatory regime we would mitigate the risk of an on-campus death or the serious bodily harm that can follow from their abuse.



It has been suggested that a regulatory regime would only fuel the black market or result in students with valid prescriptions being antagonized. I believe that our proposed changes would both prevent the spread of these drugs in the first place through education, as well as allow a more effective shutdown of any illegal market through a more transparent and clear regulatory mechanism.



Arguments have been made that the unauthorized use of these drugs is not a form of academic dishonesty or cheating.



As with any legal evaluation, intent of an action informs its criminality. The fact of the matter is, students are abusing these drugs because they feel it gives them an edge. Were a student to be caught trying to copy off another’s exam, even if they accidentally misread their neighbor’s answers, they would still be in violation of the honor code. There is a population of our student body that considers these drugs to be their illegal lifeline, their silver bullet in the form of a small orange or blue pill, that risks not only their bodily and mental health but also violates the law. Consider the reason we all find ourselves here pursuing a prestigious liberal arts degree. We’ve chosen rigor, challenge, and accepted the burden and hard work that our professors, colleagues, and administrators expect of us.



These prescription medications were invented to be equalizers to level the playing field for those with conditions like ADD and ADHD, for whom classroom environments present distinct challenges. The drugs were both created and are only legally provided for those who have a distinct requirement for them.



In fact, students that are prescribed these medications for their own needs face a risk of their medications being stolen or being pressured to give away or sell it to others who want to make use of them without following the legal and medical procedures required.



The university has an obligation to look after the welfare of students both academically and physically. The physiological effects of abusing the drugs have been undisputed in this debate between concerns over potentially fatal alcohol poisoning, and a restructuring of the brain chemistry that fundamentally changes the way that we are able to think. College lasts four years, and many take it as a sprint. But life is a marathon, and preparedness requires the ability to overcome challenges.



Emory University prides itself as a space where academically engaged, ethically concerned students can become global thinkers, collaborative individuals, and productive and fair members of society. Through this commitment to the liberal arts and accountability, it draws a diverse and engaged base of students, who are each given resources to complete an outstanding four-year experience. We believe the role of the university is to maintain this space, while ensuring the safety and integrity of its students, which can require intervention when students are known to be partaking in dangerous activities. We believe that through a changed policy the public stance of the university can both shift norms and educate regarding the dangers of study drugs.



Ramifications to community, mind, and body alike demand a reexamination of the study drug problem and the implementation of a regulatory regime to officially sanction and mitigate the abuse of these drugs on our campus. Thank you.




The Second Negative Speech


By: Mike Demers 



My first observation: the supposed obviousness of ADHD is not so obvious. Indeed, Dr. Bruce Perry said ADHD should not be considered  “a real disease.” In fact, “It is best thought of as a description. If you look at how you end up with that label, it is remarkable because any one of us at any given time would fit at least a couple of those criteria.”



The preceding speeches have uncritically accepted and moved from an assumption based on abstraction and pathologization of behavior deemed evidence of the “psychological phenomenon” of ADHD. Focus is only arbitrarily measurable and is influenced by complex factors that unsettle the supposedly objective nature of this phenomenon.



There is no evidence to suggest that AlcoholEDU lowers alcohol consumption on campus; throwing facts and expert knowledge at an individual who desires a substance does little to change it.



Moreover, what of nicotine and coffee, both of which heighten cognitive function? Are those not also cheating under this interpretation?



My second observation: naming of cheating, or moral deviance, and destructive health practices bound up in alternative ways of consuming and being in the world more generally, are not neutral. I insist they must be understood in the context of broader systems of injustice such as exploitative economic power relations immanent to capitalism. The privileging of this academic “edge” or pharmaceutical force as a primary instance of cheating relies on an assumption that we can return to an equal plane that would exist without these drugs. This is an erasure of the complexity and multiplicity of injustices I only began to explicate above.



Even more compellingly, these drugs are generative of a heightened spirit. Paul Erdö was a Jewish-Hungarian mathematician and an avid user of amphetamines before these substances were ever regulated. After abstaining from use for a month, he remarked that mathematics had been set back by a month.



ADHD, indeed, might very well be nothing more than a construct applied to particular modes of subjectivity which fail to meet the demands of production.



The regulation of study drugs is an illiberal war fought for liberal values. The prolific German philosopher Friedrich Nietzsche remarked: “Liberal institutions cease to be liberal as soon as they are attained: later on, there are no worse and no more thorough injurers of freedom than liberal institutions. Their effects are known well enough: they undermine the will to power; they level mountain and valley, and call that morality; they make men small, cowardly, and hedonistic—every time it is the herd animal that triumphs with them…The war for liberal institutions, which, as a war, permits illiberal instincts to continue.”










Dr. Jason Ciejka’s Commentary





As long as there have been tests, there has been cheating. Some of the methods have not changed much at all: sneaking a peek at a neighbor’s exam or hiding a crib note. But other ways have only emerged as new technologies have developed. Plagiarism (and its detection) became easier with the rise of the internet; online translators created problems for foreign language classes; and the prevalence of smart phones provided a new and constant temptation during exams. One of the more recent developments has been the use (or perhaps abuse) of study drugs by students without prescriptions. This practice represents a particularly thorny problem in the field of academic integrity not only because of the difficulty of enforcing any potential regulations but also because of serious disagreements about whether it even constitutes academic dishonesty.



The forum on study drugs was generated entirely through the interest of students on Emory’s Committee on Academic Integrity who sensed that the use of study drugs was a problem for some of their peers. The members also recognized that there had been little sustained discussion on campus about the nature of this practice or solutions for addressing the issue. The forum proved to be a frank and open discussion about different facets of this subject, touching upon the state of research, the ethics of study drugs, questions about their efficacy and risks, and the potential role of the university in curbing the practice. As topics in academic integrity so often do, the forum also opened up a broader conversation about the purpose of a university education.



As someone responsible for educating students about academic honesty, I was left with more questions than answers (a sure sign of the forum’s success). There are serious gaps in the research about study drugs, and without more data, policies to address the issue could be impractical or counterproductive. However, the forum’s debates and presentations helped get at the heart of why many students consider the use of non-prescribed study drugs dishonest. If study drugs are in fact effective, then they could create an unfair playing field. A student who can afford the pills, has access to them, and is willing to look past the legal implications could gain an advantage on a test or assignment. From this perspective, the act might not seem all that different from a student who accesses an unauthorized test bank or takes six hours—instead of the required three—to complete a take home exam. The issue might look very different in a few decades as medicine advances and the body of research grows. But for now, I think the key lies in educating students about the potential legal and physical risks involved in taking non-prescribed medications and reminding them of the joy of learning for its own sake.

_________________________________________________________________________



"The discussion and turnout at the event demonstrated broad interest both in the topic of study drugs and in the nature of the Honor Code at Emory. Our speakers from the Emory Center for Ethics offered a perspective that balanced well with our speaker from the Office of Health Promotion...This event went almost exactly as I had imagined during our brainstorming in November 2013, which makes me enthusiastic about the potential for student leaders to develop campus-wide programs dealing in topics that ethically engage students from diverse areas of the university."    

                                                  -- Grant Schleifer, the event coordinator






Want to cite this post?



Emory Neuroethics Program. (2015). A Special Event Reprise: Exploring the Ethics of Cognitive Enhancement and the University's Policy at Emory. The Neuroethics Blog. Retrieved on , from http://www.theneuroethicsblog.com/2015/04/a-special-event-reprise-exploring.html


Tuesday, April 14, 2015

Adderall as a motivational enhancer

Prescription stimulant use is on the rise at college campuses, especially at elite schools where the pressure and demands can be overwhelming. Students have a variety of methods to handle the stresses of their studies, but the consumption of prescription stimulants, such as Adderall or Ritalin, has become more popular among healthy individuals. While this trend raises multiple important ethical issues, the interesting idea that prescription stimulants may be masking authentic versions of ourselves was the topic of the most recent Neuroethics in the News discussion. Facilitated by AJOB Neuroscience editorial intern Ryan Purcell and AJOB Neuroscience Editor John Banja, the discussion centered around a recently published article by Torben Kjaersgaard entitled “Enhancing Motivation by Use of Prescription Stimulants: The Ethics of Motivation Enhancement."1







                                                                from Smart Drug Smarts





The cognitive enhancement debate is not new; scholars have been considering the ethical dilemmas, such as equal access, safety, coercion, and cheating, of healthy individuals seeking enhancement via prescription drugs for almost a decade.2,3 There is also a debate surrounding whether or not current stimulants are even cognitive enhancers at all, which would render the discussion irrelevant.4,5 Kjaesrgaard doesn’t focus on any of these issues though, and instead presents the ethical dilemmas associated with motivational enhancement of drugs such as Adderall and modafinil. He argues that these stimulants are not eliciting performance enhancement, but instead performance maintenance and sometimes increased motivation for a task, and this can often be ethically problematic. While the future may hold cognitive enhancers that have the ability to increase a person’s capability to solve a task or make an individual “smarter,” current stimulants promote wakefulness, arousal, and stimulation. The invocation of these emotions is related to motivation, and Kjaersgaard argues that motivation enhancement is an important but “neglected subitem in the bioethical debate on cognitive enhancement.”1


 


 Motivation in this article is defined as a “broad set of affective states that influence whether a person will voluntarily use their cognitive ability in the performance of a task,” which comes from a paper by IIieva and Farah.3 Very few papers have reported on the reasons for consumption of prescription stimulants by healthy individuals, but the article alludes to a recent qualitative study published by Scott Vreko6 to show that students who take these stimulants are typically seeking to enhance their motivation and interest during an “Adderall” day spent studying in the library. Vrecko reported four experiential “feelings” that students experience when taking Adderall including feeling up, drivenness, interestedness, and enjoyment; feelings all related to motivation. Many of the students were unable to study unless taking the drug or felt they were more effective and interested when under the influence. It is possible that these students could be self-medicating depression or ADHD, and as problematic as that may be, what if these students are just lazy? (Kjaersgaard does note that many of the students only attribute their inability to study to factors related to school, suggesting depression is not an underlying factor). Is there really anything wrong with trying to become a more productive, studious person? If a boost in motivation is needed to study for a midterm or prepare a presentation at work, is there anything ethically fraught about seeking an external stimulant? Or, is intrinsic motivation somehow more meaningful than motivation induced by prescription stimulants? The answer, according to Kjaersgaard, is sometimes. 





Lack of motivation could be part of a much larger problem connected to the meaning, structure, and purpose in a person’s life. The constant use of prescription stimulants to get through four years of college or every task at work could signal feelings of alienation, and treating these feelings with pharmaceuticals is unethical.  A student who enjoys learning and finds it self-fulfilling, but needs to take Adderall to get through one class unrelated to his major is not participating in an unethical act because the one-time use does not change the course of his life or who he is. Most importantly, this student isn’t trying to escape from reality. However, Adderall is not helping the student that is trying to get through college as a biology major because his parents want him to go to medical school. In this instance, the student is on a path of becoming his least authentic self, a complex issue that should not be controlled with prescription stimulants. Continually using stimulants to overcome a lack of willpower means that “we risk losing touch with ourselves in some sense.”1 When we start to regard lack of motivation as a physiological problem, instead of a vice, we are losing an essential part of the human condition and we are perhaps only masking the most authentic version of ourselves. 






                                                               from DistanceAdvising





 This twist on the cognitive enhancement debate is interesting because for the first time we live in a society where the quest to become what you may consider your most authentic self is actually possible.  Serfs in the Middle Ages were not questioning whether or not serfdom was their actual calling, and classes were still starkly divided as late as the 19th century. Some have made the claim that we should take cognitive enhancers because we have an obligation to society to be the best, smartest, most productive versions of ourselves. But, do we instead have an individual obligation to become the most authentic, true version of ourselves? Is it even possible to find your most authentic self? And, as Dr. Banja pointed out with this Monty Python sketch, what if your true self is boring and dull? In this case the use of prescription stimulants may not be holding you back in the slightest.  





While it may be true that the fate of college students does not drastically depend on prescription stimulant use, perhaps rampant Adderall consumption is a chance to have a conversation regarding the collegiate atmosphere. In college and in life, we move at a faster pace than before and ubiquitous technology means that something or someone is constantly demanding attention. This can often make life seem overwhelming and challenging, but by accepting the occasional Adderall usage, are we ignoring other fundamental problems with our social structure? Maybe prescription stimulants are a solution for the vast majority of people that are unsatisfied with their jobs, especially if income is a priority over authenticity. But, does society suffer at all if every person is trying to be productive, but is sacrificing essential pieces of what makes us human to get there? 





References: 


(1)          Kjærsgaard, T. Enhancing Motivation by Use of Prescription Stimulants: The Ethics of Motivation Enhancement. AJOB Neurosci. 2015, 6 (1), 4–10.


(2)          Chatterjee, A. Cosmetic Neurology: The Controversy over Enhancing Movement, Mentation, and Mood. Neurology 2004, 63 (6), 968–974.


(3)          Ilieva, I. P.; Farah, M. J. Enhancement Stimulants: Perceived Motivational and Cognitive Advantages. Front. Neurosci. 2013, 7.


(4)          Lucke, J. C.; Bell, S.; Partridge, B.; Hall, W. D. Deflating the Neuroenhancement Bubble. AJOB Neurosci. 2011, 2 (4), 38–43.


(5)          Smith, M. E.; Farah, M. J. Are Prescription Stimulants “Smart Pills”? The Epidemiology and Cognitive Neuroscience of Prescription Stimulant Use by Normal Healthy Individuals. Psychol. Bull. 2011, 137 (5), 717–741.


(6)          Vrecko, S. Just How Cognitive Is “Cognitive Enhancement”? On the Significance of Emotions in University Students’ Experiences with Study Drugs. AJOB Neurosci. 2013, 4 (1), 4–12.






Want to cite this post?



Strong, K. (2015). Adderall as a Motivational Enhancer. The Neuroethics Blog. Retrieved on , from http://www.theneuroethicsblog.com/2015/04/adderall-as-motivational-enhancer.html

Tuesday, April 7, 2015

On Killing: Neuroscience and State-Sponsored Executions

A number of botched executions over the past 16 months have reopened national discourse about the relevance of capital punishment in the 21st century, which has been polarized by passage of a Utah bill reinstating use of the firing squad. As of March 2015, the United States is the lone Western power and one of only 36 nations (18%) worldwide that executes its own citizens. Some common points of contention against state-sponsored execution include, but are certainly not limited to: cases of wrongful execution; distributive injustice, whereby racial minorities are disproportionately executed; diminished mental capacity, which may limit the perpetrator’s moral discernment and decision-making abilities; and insufficient evidence of its deterrent effect on other criminals. On the other hand, death penalty supporters often speak from two conventional perspectives about punishment: (1) a consequentialist perspective – that capital punishment will protect society against that particular convict’s future crimes, and/or (2) a retributivist perspective – namely, an intuitive notion of “an eye for an eye,” that people deserve punishment in proportion to the evilness of their past misdeeds. It’s important to note that retributivists also require proof of criminal intent, known as mens rea. While both sides of the conversation about capital punishment raise defensible points that are worthy of debate, and other perhaps more compassionate approaches to punishment exist, I’ll focus here on the two perspectives most supportive of capital punishment, which neuroscience may have the capacity to inform.



The relevance of both perspectives – consequentialist and retributivist – in this debate is demonstrated in the recent high-profile case of Kelly Gissendaner, the State of Georgia’s only female death-row inmate. Hundreds of faith leaders cite Kelly’s psychological transformation during her time in prison when they insist that the State grant her clemency, which speaks to a consequentialist approach to justice: Kelly is no longer a threat to others, and therefore taking her life, versus lifetime imprisonment, is unwarranted and unjust. By contrast for the pure retributivists, rehabilitation is irrelevant when meting out an individual’s punishment. Such a position was recently articulated by Danny Porter, the District Attorney for Gwinnett Country (GA), who stated that "[Kelly's] sentence is appropriate for the crime that was committed...and really what she's done since is almost not something that needs to be considered." These two perspectives are not necessarily mutually exclusive, but public discourse in this case tends to divide opponents and supporters along consequentialist and retributivist lines, respectively. So how can neuroscience, and possibly neurotechnology, speak to these perspectives?







Consequentialist arguments in the Gissendaner case – that Kelly is rehabilitated and no longer a threat to society – align with our contemporary understanding of neuroplasticity in that the adult brain is capable of profound structural and functional modifications through training and experience. Empirical research using interventions such as meditation [1], yoga [2], and psychotherapy [3], has demonstrated that neural changes correspond with changes in cognition and behavior, particularly in domains that are relevant to morality and criminality, like “empathic accuracy” [4] and “emotional reactivity” [5]. To that end, neurotechnologies like functional magnetic resonance imaging (fMRI) could in theory provide physical evidence of rehabilitation, which might mitigate a defendant’s punishment during parole board proceedings. To my knowledge, this sort of “functional evidence” of rehabilitation has yet to be admitted in court, but carries with it at least one major caveat. In most fMRI research studies, conclusions are based upon group comparisons (e.g. control vs. treatment groups), rather than a single individual’s brain per se. This means that simply scanning one’s brain is insufficient to infer group membership (known as the G2i problem) due to large inter-individual differences in brain activity. In other words, a person’s brain may “look” criminal, but he or she may perform normally on cognitive tests, or vice versa. The take-home message is that behavioral interventions aimed at rehabilitation can and often do have measured, lasting effects on the brain and behavior; however, generating and admitting such functional neuroevidence in court is problematic, at least given our current neurotechnological repertoire.



Retributivist arguments in the Gissendaner case – that Kelly deserves the death penalty for her involvement in taking another’s life – implicitly require that Kelly’s actions were uncoerced, intentional, and autonomous. Kelly can only be held responsible if these conditions are satisfied. Without this assumption, someone could be punished if her crime was compelled by external factors, like being forced at gunpoint to break into someone else’s car. The notion of external factors seems clear at first, but gets complicated in cases like brain tumor-induced pedophilia, or those with gene variants linked to impulsivity and violence [6]. Is one’s brain, and by extension one’s biology, an internal or external factor, or perhaps both? As researchers Joshua Greene and Jonathan Cohen suggest in their 2004 article [7], neuroscience may change criminal justice through shifts in the public’s understanding of human behavior, specifically its notions of  free will and autonomy. As neuroscience continues to discover the myriad ways in which behavior, and inextricably the human brain, is shaped by interactions of biological, psychological, and social forces that include genetics, early-life experiences, cultural environments, and human relationships, individuals will no longer judge others as completely autonomous agents making freely-willed, internal choices. Instead, they will recognize that nobody develops, perceives, thinks, and acts in such a way that is totally free from the many external forces that ultimately converge upon their brains and bodies. In that way, everyone is a little “unfree,” though some more than others. It is my hope that this scientifically-informed perspective will lead to more compassionate, humanistic approaches to criminal justice than the present system allows.



Retributivists beware: the idea of an entirely freely-willed crime may soon die.



References



1. Tang, YY, Holzel, BK, Posner MI. The neuroscience of mindfulness meditation. Nat. Rev. Neurosci (2015) 16, 213-25.



2. Gard, T, et al. Fluid intelligence and brain functional organization in aging yoga and meditation practitioners. Front Aging Neurosci (2014) 6, 76.



3. Linden, DEJ. How psychotherapy changes the brain – the contribution of functional neuroimaging. Mol Psychiatry (2006) 77, 775-81.



4. Mascaro, JS, et al. Compassion meditation enhances empathic accuracy and related neural activity. Soc Cogn Affect Neurosci (2013) 8, 48-55.



5. Taylor, VA, et al. Impact of mindfulness on the neural responses to emotional pictures in experienced and beginner meditators. Neuroimage (2011) 57, 1524-33.



6. Meyer-Lindenberg, A., et al. Neural mechanisms of genetic risk for impulsivity and violence in humans. PNAS (2006) 103, 6269-74.



7. Green, J. & Cohen, J. For the law, neuroscience changes nothing and everything. Phil. Trans. R. Soc. Lond. B (2004) 359, 1775-85.





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Kohn, J. (2015). On Killing: Neuroscience and State-Sponsored Executions. The Neuroethics Blog. Retrieved on , from http://www.theneuroethicsblog.com/2015/04/on-killing-neuroscience-and-state.html